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Indications for Insulin Therapy:
All individuals with Type 1 diabetes
Type 2 diabetes not adequately controlled by other forms of therapy (drugs, diet and exercise)
Individuals with Type 2 diabetes during periods of physiological stress (major surgery, infection)
Diabetic ketoacidosis (DKA)
Hyperosmolar hyperglycemic nonketotic syndrome (HHNS)
Secondary diabetes (pancreatitis, corticosteroids)
Physiological Secretion and Functions of Insulin:
The body's homeostatic system maintains a uniform blood glucose level between meal times and fasting periods. Basal insulin secretion maintains a balance against high blood sugar during the resting state.
The insulins available for routine clinical use are derived from three sources beef, pork and human (recombinant).
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