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INSULIN THERAPY
Very long acting: Lantus (Fig.7): Lantus is newer insulin,
which works for 24 hrs. The chemical structure of Lantus makes
it to be released steadily and continuously in the body, mimicking
almost the basal physiological secretion of Insulin. It is the
only long acting insulin which is clear and cannot be mixed up
with any other insulin.
Regular insulin, Lispro and Aspart are only clear insulins or solution of insulin. Regular insulin modified with addition of protamine and zinc (NPH) or zinc alone (Lente, Ultralente) to prolong duration of action of insulin are cloudy white suspensions.
Lispro is an insulin analog identical to human insulin except for the reversal of two amino acids, lysine and proline, on the B chain.
Fig 7: Peak and Duration of Action of Very Long Acting Insulins

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