Steroid Responsive - Pediatric Oncall

4th Pediatric Infectious Diseases Conference

ISSN 0973 - 0958

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Question
Dear sir, My grandson aged 3yrs and 2 months is suffering from NEPHROTIC SYNDROME. Last August, he was on oral Prednisone of 30 mg /day for 6 weeks and later on 20mg every alternate day for 6 weeks. Later it was stopped. His protein in urine had come to traces within two days after start of medicine. He has relapsed it in last December after suffering from cold and cough. Protein in his urine remained more than +2 since two weeks. 30 mg of oral Prednisone/ day has been started again since last 4 days. But this time Protein in his urine is still +3. The drug is not responding as it had responded earlier. Does it require Kidney Biopsy? Please suggest us the various alternative. He often urinates small amount of urine say few drops many times a day. He is also very aggressive in nature and tries to do what we say not to be done and stubborn. Please help us and guide us. Thank you
Answer
Since he had responded to prednisolone the last time, he seems to be steroid responsive. Since this time the relapse was due to infection, once the infection settles and the action of prednisolone starts, he should go into remission. If inspite of being on prednisolone, his urine protein remains 3+ or more after more than 4 weeks of steroids, then he would require further evaluation. Back to All Questions

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