Nephrotic Syndrome for a 12 years child

4th Pediatric Infectious Diseases Conference

ISSN 0973 - 0958

Childhood Ailments

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Question
My son ( 12 years + )is suffering from Nephrotic Syndrome for the last 7 months. We appreciate your valuable time to response us with your special advise. He has leakage of Protein in Urine. 9.2 grms in 24 hour. A brief history as follows, 1. Problem detected. 25.5.2002. Urine analysis shows 3 grm protein in urine. 2. Two months medication taken but no result came. 3. Kidney Biopsy done : 02.8.2002. and result came 20.8.2002. from Germany. 4. Result : Combination of minimal chain disease & Mesangio proliferative IgA nephrities. 5. New medicines started with Cellcept (Mycophenolate Mofetil ) & Sandimmum Neoral (Ciclosporin 25 mg). after seeing the result. 6. No positive result came and Medicine changed again on. 25.9. 2002. Stopped Cellcept / Neoral and start Endoxan (Cyclophosphamide) with 50 mg daily later on 26.10.2002 increased dose to 50 mg Morning / 50mg Evening daily. 7. The last report shows 14 grm in 24h Urine on 02.12.2002. Seems no response shows till today. Kidney function are ok. 8. Medicine details report attached herewith to see the time and kind of medicine. Being Parent we are really concern about our child and his treatment and trying our best to make possible cure. We really appreciate your advise to this case. Your valuable time being spent for us will be appreciated and will be reworded by the GOD almighty. Your feed back of Medicine / side effects & treatment also other important guideline are awaited. Best Regards,
Answer
It seems that your son has received the proper medications but the time period seems to be short for them really to show any effect. Also the best option would be to give him IV Methyl Prednisolone (high dose steroids intravenously) initially every alternate day for 6 times then increasing the duration. However these agents need to be taken under the guidance of an expert nephrologist as they may lead to severe toxicity such as hypertension, thinning of bones and even cataracts. Back to All Questions

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