Immunization Schedule - Expanded Programme, WHO recommendations - Immunization
 
IMMUNIZATION SCHEDULE
Last Updated : 2/15/2016
Sayenna Uduman
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Adverse Events of Vaccines
All vaccines undergo rigorous safety and efficacy/immunogenicity testing prior to licensure & marketing. However, adverse events after vaccination occasionally occur. Many adverse events may be coincidental events that occur in temporal association after vaccination but are unrelated to vaccination.
Common vaccine adverse reactions usually are mild to moderate in severity (e.g., fever or injection site swelling, pain & redness) and have no permanent sequelae. This include local inflammation after administration of DTwP, Td, or Tdap vaccines, and fever and rash 1 to 2 weeks after administration of MMR or MMRV vaccines.
A new systematic review of adverse events linked to routine childhood vaccines has found that vaccines associated with serious adverse events are “extremely rare and must be weighed against the protective benefits that vaccines provide.” (.Pediatrics vol. 134 No.2, Aug 2014 pp377- 79).
The following are among the findings of the review commissioned by the Agency for Healthcare Research and Quality (AHRQ):
• MMR & Autism link: MMR vaccine was not associated with the onset of autism (based on evidence with high confidence).
Rotavirus vaccine and Intussusception link: an extremely rare occurrence (moderate evidence)
• MMR, DTaP, Hib vaccines have shown no association with leukemia (high strength evidence).
• Varicella — associated with thrombocytopenic purpura in youths 11-17 years (moderate evidence)
• Vaccines rarely cause life-threatening allergic reactions: [Just 33 people from 25 million immunized were affected, CDC researchers report]

References

Contributor Information and Disclosures

Sayenna Uduman
Sayenna A Uduman MD, FAAP
Visiting Professor, Infection Control Committee & ID Division of the KIMS
Thiruvananthapuram, Kerala, India


First Created : 1/9/2001
Last Updated : 1/9/2014

References

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