Pneumococcal Vaccine – Types, Dosing And Schedule - Immunization
Last Updated : 2/29/2016
Sayenna Uduman
Types of pneumococcal vaccines
There are currently two kinds (Polysaccharide & Conjugated type) of licensed pneumococcal vaccines for clinical use.

Conjugate vaccines types
They are immunogenic and T cell dependent. Before implementation of routine pneumococcus immunization in infants with 7 valent conjugate vaccine (PCV7), serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F caused most IPD in the United States; these seven STs were contained in PCV7. In 2010, the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced and includes types 1,3,5,6A,7F, and 19A in addition to the serotypes in PCV7.

Conjugated vaccines are developed for universal childhood immunization of infants and children as early 6 weeks of age and are now recommended for childhood immunization. The pneumococcal polysaccharide capsular antigens are individually conjugated to a diphtheria membrane carrier protein (CRM197).

Non-conjugate Capsular polysaccharide 23 valent vaccine (PPSV23)
It is meant for high risk children > 2 years and adults. The PPSV23 protects and cover 10 additional STs that are contained in the PCV13 formulation. The PPSV23 is poorly immunogenic, short lived immunity & are not protective for children younger than 24 months of age. Not useful at infancy for universal immunization purposes. Nonetheless PPSV23 vaccine is indicated for patients 2 years of age and older with high risk clinical situations and this vaccine have been in clinical practice over 3 decades.


Contributor Information and Disclosures

Sayenna Uduman
Sayenna A Uduman MD, FAAP
Visiting Professor, Infection Control Committee & ID Division of the KIMS
Thiruvananthapuram, Kerala, India

First Created : 1/10/2006
Last Updated : 2/29/2016


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