Rubella vaccine – Efficacy, Age Of Administration, Contraindications - Immunization
Last Updated : 8/1/2015
Jagdish Kathwate
What is Rubella vaccine?
Rubella vaccine is available either as single antigen vaccine or combined with measles and mumps (MMR). It contains live attenuated RA 27/3 strain of rubella virus, propagated in human diploid cells.

What is efficacy of RA 27/3 Rubella vaccine
It is highly efficacious. In clinical trials, 95% - 100% of susceptible individuals aged 12 months or above developed rubella antibodies by 3-4 weeks after vaccine administration. Vaccine-induced immunity is generally lifelong.

What is ideal Age of administration?
Rubella vaccine is usually given at age 12-15 months, but can also be administered to children as young as 9 months of age. It may also be administered to older children, adolescents, students, childcare personnel, health care workers, military personnel and adult men in contact with women of childbearing age.

What are Contraindications for rubella vaccine?
History of anaphylactic reaction to neomycin or an anaphylactic reaction after a previous dose of rubella.
Advanced immunodeficiencies e.g. congenital immune disorders, malignancies and immuno suppressive therapy.

What are Adverse events of rubella vaccine?
They are generally mild. Common symptoms are pain, redness and induration at the site of injection, low-grade fever, rash, lymphadenopathy, myalgia & parasthesia.

What is Need for rubella vaccine?
The primary purpose of rubella vaccination is to prevent the occurrence of congenital rubella infection, which is an important cause of deafness, blindness and mental retardation in the child affected.


Contributor Information and Disclosures

Jagdish Kathwate
MD Pediatrics. Assistant Professor, Government Medical College, Aurangabad, India.

First Created : 1/10/2001
Last Updated : 8/1/2015


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