http://www.pediatriconcall.com/forpatients/commonchild/immunity/immunity.asp Power of resistance to infection is called Immunity.Our immune system is important for maintaining immunity in the body and preventing infections. It is made up of variety of body cells and proteins. Infact the first barrier to infection is the skin and the mucus membranes that line the nose, lungs and intestines. en-us 2012-02-24T19:04:26.0000000+05:30 http://www.pediatriconcall.com/rss_media/rss_rss_Immunity.jpg http://www.pediatriconcall.com/forpatients/commonchild/immunity/immunity.asp Immunity is the ability to give Protection from Infectious Diseases. http://www.pediatriconcall.com/forpatients/commonchild/immunity/immunity.asp 2012-02-24T00:00:00.0000000+05:30 Our immune system is important for maintaining immunity in the body and preventing infections. It is made up of variety of body cells and proteins. Infact the first barrier to infection is the skin and the mucus membranes that line the nose, lungs and intestines. Our environment contains lot of bacteria and viruses. The skin and mucus membranes act as physical barriers and prevent entry of these germs into our body and internal organs. http://www.pediatriconcall.com/forpatients/commonchild/immunity/immune_system.asp 2011-03-26T00:00:00.0000000+05:30 Common variable immunodeficiency (CVID) is a primary Immunodeficiency in which patients have low levels of serum immunoglobulins (antibodies) and an increase susceptibility to infections. In some patients, there is decrease in both IgG and IgA; in others all three antibodies IgG,IgA and IgM may be decreased. http://www.pediatriconcall.com/forpatients/commonchild/immunity/cvid.asp 2011-03-26T00:00:00.0000000+05:30 XLA is a primary immunodeficiency in which patients are unable to produce antibodies (immunoglobulins). As a result, these patients are prone to get recurrent bacterial infections. XLA is also called as Bruton's agammaglobulinemia or congenital agammaglobulinemia. http://www.pediatriconcall.com/forpatients/commonchild/immunity/xla.asp 2011-03-26T00:00:00.0000000+05:30 Selective IgA deficiency is a primary immunodeficiency in which IgA immunoglobulin is deficient in the blood and in the respiratory and intestinal tracts. IgA antibodies predominantly protect us from respiratory infections and diarrhea. http://www.pediatriconcall.com/forpatients/commonchild/immunity/iga.asp 2011-03-26T00:00:00.0000000+05:30 SCID is a rare primary immunodeficiency disorder in which there is combined absence of T-lymphocyte and B-lymphocyte function. It can lead to extremely serious infections which can even be fatal. http://www.pediatriconcall.com/forpatients/commonchild/immunity/scid.asp 2011-03-26T00:00:00.0000000+05:30 When part of the immune system does not function properly, it leads to recurrent infections. The immune deficiency may be inborn and is called primary immunodeficiency. http://www.pediatriconcall.com/forpatients/commonchild/immunity/immunodeficiency.asp 2011-03-26T00:00:00.0000000+05:30 Immunoglobulins are also called as antibodies. They are special proteins formed by the B-lymphocytes that attach to a microorganism and help to kill the germ by easy ingestion by phagocytes. http://www.pediatriconcall.com/forpatients/commonchild/immunity/ivig.asp 2011-03-26T00:00:00.0000000+05:30 In patients with genetic disorders due to mutation in a gene, the defective gene leads to a disease. With gene therapy the correct genes are infused inside the body or into patient's stem cells in the laboratory by piggybacking them on a non-functional virus. http://www.pediatriconcall.com/forpatients/commonchild/immunity/gene_therapy.asp 2011-03-26T00:00:00.0000000+05:30 Hyper IgE syndrome (HIES) is also known as Job’s syndrome. It is a primary immunodeficiency where recurrent skin boils, eczema and pneumonia are seen. http://www.pediatriconcall.com/forpatients/commonchild/immunity/hyper_ige.asp 2011-03-26T00:00:00.0000000+05:30 Complements are group of proteins in blood that help to fight infection. The complement system includes at least 30 proteins of which the common ones are C1, C2, C3, C4, C5, C6, C7, C8, C9, Factor B, Factor D & C1 inhibitor. http://www.pediatriconcall.com/forpatients/commonchild/immunity/complement_deficiencies.asp 2011-06-18T00:00:00.0000000+05:30 Wiskott-Aldrich syndrome is also called as WAS. It is a primary immunodeficiency that affects T-lymphocytes, B-lymphocytes as well as blood cells that control bleeding called as platelets. http://www.pediatriconcall.com/forpatients/commonchild/immunity/wiskott.asp 2011-08-01T00:00:00.0000000+05:30 Our body produces various types of antibodies from the B-lymphocytes. These antibodies help to fight infection. The antibodies are IgA, IgD, IgE, IgM & IgG. Usually with infections the initial antibody to form is IgM which then switches to IgG, IgA or IgE. In patients with hyper IgM (HIM) syndrome, there is inability to switch IgM to IgG, IgA or IgE type. Thus patients are susceptible to infections. http://www.pediatriconcall.com/forpatients/commonchild/immunity/hyper_igm.asp 2011-08-01T00:00:00.0000000+05:30 DiGeorge syndrome is a genetic disorder due to deletion in Chromosome 22 This leads to abnormal and poor development of the parathyroid gland, thymus and heart. http://www.pediatriconcall.com/forpatients/commonchild/immunity/digeorge.asp 2011-09-01T00:00:00.0000000+05:30 IgG subclass deficiency is a type of primary immunodeficiency where subclasses of IgG are deficient leading to recurrent infections. The body produces 5 types of immunoglobulins - IgA, IgM, IgD, IgE & IgG which help to fight infection. http://www.pediatriconcall.com/forpatients/commonchild/immunity/igg.asp 2011-09-01T00:00:00.0000000+05:30 Chronic granulomatous disease also called as CGD is a primary immunodeficiency where the body's cells (phagocytes) are unable to kill the germs. http://www.pediatriconcall.com/forpatients/commonchild/immunity/cgd.asp 2011-10-01T00:00:00.0000000+05:30