Probiotics

 
print
Probiotics
Definition
Probiotic has been defined as "live microorganisms which when administered in adequate amounts confer a health benefit on the host" as determined by an expert panel convened by the FAO (1).

Actions of probiotics
Probiotic bacteria benefit the host by adhering to the gut epithelium, stimulating host immune response, inhibiting epithelial and mucosal adherence of pathogens and producing antimicrobial substances (2). Probiotics have the potential to impact physiologic and metabolic parameters which are influenced by normal indigenous microbes, such as immune system maturation, gut barrier function, levels of metabolic end products available to alter luminal conditions or serve as substrates to epithelial cells, binding or degradation of potential carcinogens, enzymatic alteration of bile acids and competitive exclusion. (3)

Uses of probiotics
There has been increasing evidence in the last decade for efficacy of probiotic agents in treatment of acute diarrhea (2), persistent diarrhea (4), and prevention of antibiotic associated diarrhea (5). Other benefits that have been documented are regulation of immune function, (6) prevention of infection, (7) prolongation of remission in patients with inflammatory bowel conditions, (8) reduction of incidence of atopic dermatitis in high risk infants, (9) control of symptoms associated with lactose intolerance, (10) decreasing symptoms for irritable bowel syndrome, (11) prevention of Helicobacter pylori colonization, (12) vaginal microbiota restoration, (13) improve growth parameters in undernourished children, (14) decrease incidence of dental caries, (15) and respiratory infections. (16)

It should be remembered that these effects have been observed for only one or a limited number of strains and other strains of even the same species cannot be presumed to demonstrate the same effects. (3)

Common probiotics used
Members of the genera Lactobacillus and Bifidobacterium are mainly used as probiotics in food supplements, but not exclusively, as probiotic microorganisms and a growing number of probiotic foods are available to the consumer. (1)

Bifidobacterium
Bifidobacterium species have a long history of safe use when consumed as part of food and supplement products. (17) No cases of clinical infection have been reported from such use. The species generally used for such applications are longum, infantis, breve, bifidum, adolescentis, and animalis (both subspecies lactis and animalis). (3)

Lactobacillus
Lactobacillus converts lactose and other sugars to lactic acid. The genus Lactobacillus currently consists of over 125 species and encompasses a wide variety of organisms. According to metabolism, the commonly used lactobacilli as probiotics are lactobacillus acidophilus, lactobacilli casei.

Safety
Probiotics should not be given to children who are seriously or chronically ill until the safety of administration has been established. With the exception of one strain belonging to the L. rhamnosus species, lactobacilli and bifidobacteria used for food production are "generally recognized as safe" (GRAS) by the Food and Drug Administration of the USA. The two strains of lactobacilli and bifidobacteria are classified as absolutely safe. (18)


Probiotics Probiotics 9/15/2014
ask doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.