Q. How much dilution of ceftriaxone and mikacin is recommended? We are giving ceftriaxone 1 gm in 100 ml ns. Can we give it in routine RL or DNS or isolyte p 500 ml drip? We are giving Mikacin without dilution. What are your recommendations?
Post Date : 20 Apr 2025
Expert Opinion:
Do not use diluents containing calcium, such as Ringer’s solution or Hartmann’s solution, to reconstitute ceftriaxone. It should be administered intravenously by infusion over a period of 30 minutes. Concentrations between 10 mg/mL and 40 mg/mL are recommended. It is stable for 24 hours at room temperature only in 0.9 percent sodium chloride injection or 5 percent dextrose in water (D5W).
Usual diluent for amikacin is NS, D5W. Amikacin sulfate is stable for 24 hours at room temperature and 2 days at refrigeration at concentrations of 0.25 and 5.0 mg, mL in the following solutions:
5% Dextrose Injection, USP
5% Dextrose and 0.2 percent Sodium Chloride Injection, USP
5% Dextrose and 0.45 percent Sodium Chloride Injection, USP
0.9% Sodium Chloride Injection, USP
Lactated Ringer’s Injection, USP