Drug Index

C1 Esterase Inhibitor

 
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Mechanism :

Believed to suppress contact system activation via inactivation of plasma kallikrein and factor XIIa, thus preventing bradykinin production.


Indication :

• Hereditary angioedema


Contraindications :

History of anaphylactic or life-threatening hypersensitivity reactions to C1 inhibitor (human) or any component of the formulation.


Dosing :

6 to 11 years: IV 500 units every 3 to 4 days; adjust dose based on individual patient response, up to 1,000 units every 3 to 4 days

Children ≥12 years and Adolescents: IV 1,000 units every 3 to 4 days; if response is not adequate, doses up to 2,500 units (≤100 units/kg) every 3 or 4 days may be considered based on individual patient response.

HAE attacks (abdominal, facial or laryngeal), treatment: Children ≥5 years and Adolescents: IV: 20 units/kg.


Adverse Effect :

Headache, nausea, injection site reactions, nasopharyngitis, dizziness, erythema, pruritus, hypersensitivity reactions, flu-like symptoms.


Interaction :

Androgens: May enhance the thrombogenic effect of C1 inhibitors.
Estrogen Derivatives: May enhance the thrombogenic effect of C1 inhibitors.
Progestins: May enhance the thrombogenic effect of C1 inhibitors.


07/18/2019 09:29:06 C1 Esterase Inhibitor
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