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Pediatric tuberculous meningitis (TBM) remains one of the deadliest and most under-recognized forms of childhood TB — with nearly 24,000 children under 15 affected globally each year and over 16,000 deaths. In this 2026 evidence-based update, Dr. Ira Shah (Professor & Head, Pediatric Infectious Diseases, B.J. Wadia Hospital for Children, Mumbai) walks through the latest diagnostic algorithms, treatment regimens, and management strategies for pediatric TBM.
Topics covered include the 2026 diagnostic algorithm, the Lancet Uniform Research Case Definition, CSF Xpert MTB/RIF Ultra and beyond, CSF host biosignatures, the NTEP first-line ATT regimen, dexamethasone and supportive care, MDR-TBM management, host-directed therapies, paradoxical deterioration, and post-TBM long-term care — including a real case study and a discussion on mixed TB infections.
Video Chapters include:
00:00 Intro
01:17 The Unfinished Burden
02:09 2026 Diagnostic Algorithm
03:39 Clinical Crietria
06:22 Lancet Uniform Research case definition
06:54 Lancet Uniform Research case definition (ctd)
07:12 Xpert MTB/RIF Ultra
08:49 Beyond Xpert Ultra
09:44 CSF Host Biosignatures
12:02 First-Line ATT for Pediatric TBM — NTEP Regimen
15:38 Clinical Profiles
16:40 Dexamethasone
18:00 Supportive Care
18:55 MDR-TBM
19:19 Building the MDR-TBM Regimen
20:36 Host-Directed Therapies
21:25 Paradoxical Deterioration
22:03 Survival Is Not Enough
22:28 Post-TBM care
23:41 Case Study
24:47 Mixed TB Infection
25:37 Pediatric TBM 2026
Read more about:
Central Nervous System Tuberculosis: https://youtu.be/H9-ALcU5sA0?si=OIQpa21RNPtHHG0e
Uncommon CNS Infections | Case-Based Insights in Immunocompromised Children: https://youtu.be/rrl89OX8-rI?si=SHYzTFisjvlUDgU0
PEDIATRIC ONCALL is the Web's most robust and integrated medical information and education tool with an extensive network of doctors as registered members.
#PediatricTBM #TuberculousMeningitis #PediatricTB #TBinChildren #CNSTuberculosis #XpertUltra #MDRTBM #PediatricInfectiousDisease #TBDiagnosis #DrIraShah #PediatricNeurology #TBAwareness #MedicalEducation #CME #Tuberculosis2026
2026-09-05
Management of Pediatric TBM 2026 – Where Are We?
Description
Pediatric tuberculous meningitis (TBM) remains one of the deadliest and most under-recognized forms of childhood TB — with nearly 24,000 children under 15 affected globally each year and over 16,000 deaths. In this 2026 evidence-based update, Dr. Ira Shah (Professor & Head, Pediatric Infectious Diseases, B.J. Wadia Hospital for Children, Mumbai) walks through the latest diagnostic algorithms, treatment regimens, and management strategies for pediatric TBM.
Topics covered include the 2026 diagnostic algorithm, the Lancet Uniform Research Case Definition, CSF Xpert MTB/RIF Ultra and beyond, CSF host biosignatures, the NTEP first-line ATT regimen, dexamethasone and supportive care, MDR-TBM management, host-directed therapies, paradoxical deterioration, and post-TBM long-term care — including a real case study and a discussion on mixed TB infections.
Video Chapters include:
00:00 Intro
01:17 The Unfinished Burden
02:09 2026 Diagnostic Algorithm
03:39 Clinical Crietria
06:22 Lancet Uniform Research case definition
06:54 Lancet Uniform Research case definition (ctd)
07:12 Xpert MTB/RIF Ultra
08:49 Beyond Xpert Ultra
09:44 CSF Host Biosignatures
12:02 First-Line ATT for Pediatric TBM — NTEP Regimen
15:38 Clinical Profiles
16:40 Dexamethasone
18:00 Supportive Care
18:55 MDR-TBM
19:19 Building the MDR-TBM Regimen
20:36 Host-Directed Therapies
21:25 Paradoxical Deterioration
22:03 Survival Is Not Enough
22:28 Post-TBM care
23:41 Case Study
24:47 Mixed TB Infection
25:37 Pediatric TBM 2026
Read more about:
Central Nervous System Tuberculosis: https://youtu.be/H9-ALcU5sA0?si=OIQpa21RNPtHHG0e
Uncommon CNS Infections | Case-Based Insights in Immunocompromised Children: https://youtu.be/rrl89OX8-rI?si=SHYzTFisjvlUDgU0
PEDIATRIC ONCALL is the Web's most robust and integrated medical information and education tool with an extensive network of doctors as registered members.
#PediatricTBM #TuberculousMeningitis #PediatricTB #TBinChildren #CNSTuberculosis #XpertUltra #MDRTBM #PediatricInfectiousDisease #TBDiagnosis #DrIraShah #PediatricNeurology #TBAwareness #MedicalEducation #CME #Tuberculosis2026