They antagonize the effects of histamine. Commonly used preparations are antistine, histantin, chlorphenirmine, promethazine

Route :
ingestion, inhalation or injection
Fatal Dose :
Mechanism of action :

Clinical Picture :
Occur due to excitation and depression of CNS
• dryness of mouth, nausea, vomiting, drowsiness, headache, blurred vision, urinary retention and nervousness
• agranulocytosis and aplastic anemia
• in large doses, fixed dilated pupils, disorientation, hyperreflexia, tremors, nystagmus, convulsions

Treatment :
• stomach wash
• Physostigmine: 0.5mg to 2mg i.v. every hour till reversal of symptoms occurs
• diazepam i.v.
02/14/2024 20:48:12 Anti-histaminics
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