Drug Index

Cerliponase Alfa

Mechanism :

Cerliponase alfa is a proenzyme that, once activated, cleaves tripeptides from the N-terminus of proteins.

Indication :

  • Neuronal ceroid lipofuscinosis type 2

Contraindications :

Acute intraventricular access device-related complications, ventriculoperitoneal shunts.

Dosing :

≥3 years:
Intraventricular: 300 mg once every other week.

Adverse Effect :

ECG abnormality, Abnormal proteins in cerebrospinal fluid, seizure, pleocytosis, headache, vomiting, hematoma, hypersensitivity reactions, antibody formation, fever, bradycardia, hypotension, jitteriness, catheter infection.

Interaction :

No known significant interactions.

Hepatic Dose :

No dosage adjustments are recommended.
03/13/2024 05:56:04 Cerliponase Alfa
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0