Drug Index

Eltrombopag

 
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Mechanism :

Eltrombopag is a thrombopoietin (TPO) nonpeptide agonist which increases platelet counts by binding to and activating the human TPO receptor.


Indication :

• Chronic immune thrombocytopenia (ITP) who have had insufficient response to corticosteroids, immunoglobulins, or splenectomy.

• Severe aplastic anemia

• Chronic hepatitis C infection-associated thrombocytopenia.


Contraindications :

Hypersensitivity to eltrombopag or any component of the formulation; severe hepatic impairment (Child-Pugh class C).


Dosing :

Chronic immune thrombocytopenia (ITP): Oral

1-5 years: Initial: 25 mg once daily; dose should be titrated based on platelet response. Maximum dose: 75 mg/day.

≥6 years: Initial: 50 mg once daily; dose should be titrated based on platelet response. Maximum dose: 75 mg/day.

Severe aplastic anemia: Oral

Initial: 50 mg once daily; dose should be titrated based on platelet response. Maximum dose: 150 mg/day.


Adverse Effect :

Influenza-like symptoms, headache, rigor, cough, diarrhea, fatigue, nausea, arthralgia, myalgia, depression, upper abdominal pain, xerostomia, abnormal LFT, thrombocytopenia, paraesthesia, vomiting, dyspepsia, thrombotic or thromboembolic complications, hemorrhage, conjunctival haemorrhage, ecchymosis, menorrhagia, cataract.


Interaction :

Calcium Salts: May decrease the serum concentration of Eltrombopag.
Iron Salts: May decrease the serum concentration of Eltrombopag.
Magnesium Salts: May decrease the serum concentration of Eltrombopag.
OATP1B1/SLCO1B1 Substrates: Eltrombopag may increase the serum concentration of OATP1B1/SLCO1B1 Substrates.
Sucralfate: May decrease the serum concentration of Eltrombopag.
Zinc Salts: May decrease the serum concentration of Eltrombopag.


07/19/2019 03:11:41 Eltrombopag
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