Drug Index


Mechanism :

Histaglobulin is a lyophilised preparation of Histamine coupled with Human Normal Immunoglobulin. Histaglobulin administered subcutaneously induces production of antibody against the histamine-immunoglobulin complex, which binds and inactivates histamine released during allergy. Repeated doses of histaglobulin increase this antibody titer, for which booster doses of histaglobulin were administered every 6 months.

Indication :

  • Pruritus
  • Eczema
  • Allergic Rhinitis
  • Bronchial Asthma
  • Urticaria
  • Atopic Dermatitis

Contraindications :

Hypersensitivity to histaglobulin is a contraindication.

Dosing :

Available as Human normal immunoglobulin (12 mg) and histamine dihydrochloride (0.15 mcg).
3 injections of 12 mg each SC at an interval of 7 days.

Adverse Effect :

May give rise to mild local reactions, fever, chills, malaise.

Interaction :

MMR: Measles, mumps and rubella vaccines should not be given 3 weeks before to 3 months after using this drug, as their efficacy may be reduced.
Immunoglobulin: Administration of any immunoglobulin preparation may raise antibody levels to a number of microorganisms, and this is important when interpreting antibody assays within 2-3 months of administration of this drug.

Hepatic Dose :

No dosage adjustments are recommended.
02/21/2024 00:18:23 Histaglobulin
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