Drug Index


Mechanism :

Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine (dopa) and suppression of other melanocyte metabolic processes. Exposure to sunlight or ultraviolet light will cause repigmentation of bleached areas.

Indication :

  • Gradual bleaching of hyperpigmented skin conditions

Contraindications :

Prior history of sensitivity or allergic reaction to hydroquinone or to any of the ingredients of the product. The safety of topical hydroquinone use during pregnancy or in children below 12 years has not been established.

Dosing :

For <12 years:
Safety and Efficacy is not established.
For >12 years:
Application of four percent cream in the morning and before bedtime on the affected areas and rubbed in well.

Adverse Effect :

Erythema, stinging, dryness and fissuring of paranasal and infraorbital areas, hypersensitivity.

Interaction :

Avoid/Use Alternative: Benzoyl peroxide topical.

Hepatic Dose :

No dosage adjustments are recommended.
03/13/2024 06:49:34 Hydroquinone
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