Drug Index

Lopinavir

 
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Mechanism :

Lopinavir, an inhibitor of the HIV protease, prevents cleavage of the Gag-Pol polyprotein, resulting in the production of immature, non-infectious viral particles.


Indication :

• Combination with other antiretroviral agents for the treatment of HIV-infection along with ritonavir


Contraindications :

Contraindicated in patients with known hypersensitivity to any of its ingredients, including ritonavir.


Dosing :

2 weeks to 6 months: 300 mg/75 mg (LPV/r)/sqm, or 16 mg/4 mg (LPV/r)/kg orally, every 12 hours.

6 months-18 years: 450 mg/sqm/day along with ritonavir 108 mg/sqm/day PO divided in 12 hours.


Adverse Effect :

Increased spontaneous bleeding in patients with haemophilia, liver function abnormalities, pancreatitis; dyspepsia, arthralgia, new onset diabetes mellitus, exacerbation of pre-existing diabetes mellitus, hyperglycemia, anaphylactoid reactions, urticaria, vasculitis, depression, oral paraesthesia, rash including erythema multiforme and Stevens-Johnson syndrome, hyperpigmentation, alopecia, paronychia, ingrown toenails, pruritus, redistribution/accumulation of body fat, urolithiasis, nephrolithiasis, increased serum cholesterol, increased serum triglycerides, myocardial infarction.


Interaction :

CYP3A Drugs: Lopinavir is an inhibitor of CYP3A (cytochrome P450 3A) both in vitro and in vivo. Co-administration of drugs primarily metabolized by CYP3A (e.g., dihydropyridine calcium channel blockers, HMG-CoA reductase inhibitors, immunosuppressants and sildenafil) may result in increased plasma concentrations of the other drugs that could increase or prolong their therapeutic and adverse effects.


07/18/2019 02:04:15 Lopinavir
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