Drug Index

Nabilone

 
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Mechanism :

Its antiemetic activity may be due to effect on cannabinoid receptors (CB1) within the central nervous system.


Indication :

• Treatment of refractory nausea and vomiting associated with cancer chemotherapy


Contraindications :

Hypersensitivity to nabilone, other cannabinoids, or any component of the formulation.


Dosing :

Oral

<18 kg: 0.5 mg every 12 hours.

18 to 30 kg: 1 mg every 12 hours.

>30 kg: 1 mg every 8 to 12 hours.

Maximum dose: 0.06 mg/kg/day.


Adverse Effect :

Drowsiness, dizziness, vertigo, euphoria, ataxia, depression, lack of concentration, sleep disturbance, xerostomia, visual disturbance, hypotension, dysphoria, headache, sedation, anorexia, nausea, weakness.


Interaction :

Anticholinergic Agents: May enhance the tachycardic effect of Cannabinoid-Containing Products.
Blood Pressure Lowering Agents: May enhance the hypotensive effect of Hypotension-Associated Agents.
CNS Depressants: Nabilone may enhance the CNS depressant effect of CNS Depressants.
Sympathomimetics: Cannabinoid-Containing Products may enhance the tachycardic effect of Sympathomimetics.


07/14/2019 07:15:35 Nabilone
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