Drug Index

Rufinamide

 
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Mechanism :

It is a triazole-derivative antiepileptic whose exact mechanism is unknown. It is known to prolong the inactive state of the sodium channels.


Indication :

• Lennox-Gastaut syndrome: As an adjunctive treatment


Contraindications :

Patients with familial short QT syndrome; hypersensitivity to rufinamide, triazole derivatives, or any component of the formulation.


Dosing :

Initial: 10 mg/kg/day PO in 2 equally divided doses; increase dose by ~10 mg/kg every other day to a maximum dose of 45 mg/kg/day, not to exceed 3,200 mg daily in 2 equally divided doses.


Adverse Effect :

Shortened QT interval, ataxia, aggressive behaviour, hyperactivity, headache, drowsiness, fatigue, vomiting, nausea, skin rash, decreased appetite, leukopenia, anemia, diplopia, blurred vision.


Interaction :

Alcohol (Ethyl): May enhance the adverse/toxic effect of Rufinamide. Specifically, sleepiness and dizziness may be enhanced.
Carbamazepine: Rufinamide may decrease the serum concentration of Carbamazepine and vice-versa.
CNS Depressants: Rufinamide may enhance the adverse/toxic effect of CNS Depressants.
Valproate Products: May increase the serum concentration of Rufinamide.


07/19/2019 03:16:04 Rufinamide
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