Drug Index

Tolmetin

 
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Mechanism :

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.


Indication :

• Juvenile rheumatoid arthritis

• Off-Label: Analgesia (children and adolescents).


Contraindications :

Hypersensitivity to tolmetin or any component of the formulation; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.


Dosing :

Oral: Initial: 20 mg/kg/day in 3 to 4 divided doses; Maintenance: 15 to 30 mg/kg/day in 3 to 4 divided doses. Maximum: 30 mg/kg/day.


Adverse Effect :

Increased liver function test, nausea, hypertension, myocardial infarction, edema, abdominal pain.


Interaction :

Aminolevulinic Acid (Systemic): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid.
Ketorolac (Systemic): May enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents.
Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective): Nonsteroidal Anti-Inflammatory Agents may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective).


07/19/2019 03:18:11 Tolmetin
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