Drug Index

Mechanism :

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.

Indication :

  • Juvenile rheumatoid arthritis
  • Off-Label: Analgesia (children and adolescents).

Contraindications :

Hypersensitivity to tolmetin or any component of the formulation; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.

Dosing :

Oral: Initial: 20 mg/kg/day in 3 to 4 divided doses;
15 to 30 mg/kg/day in 3 to 4 divided doses.
30 mg/kg/day.

Adverse Effect :

Increased liver function test, nausea, hypertension, myocardial infarction, edema, abdominal pain.

Interaction :

Aminolevulinic Acid (Systemic): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid.
Ketorolac (Systemic): May enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents.
Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective): Nonsteroidal Anti-Inflammatory Agents may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents (COX-2 Selective).

Hepatic Dose :

Use cautiously. Dose reduction may be needed. Monitor carefully any patient with abnormal liver function tests.
09/24/2020 18:30:16 Tolmetin
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