ISSN - 0973-0958
NEONATAL EMPYEMA THORACIS 08/28/2017 00:00:00 https://www.pediatriconcall.com/Journal/images/journal_cover.jpg
   
 
NEONATAL EMPYEMA THORACIS
Seema Sharma, Ajay Sharma, Milap Sharma, Saugat Ghosh
Department of Pediatrics, Dr Rajendra Prasad Government Medical College, Himachal Pradesh, India.
Address for Correspondence
Dr Seema Sharma, House no 23, Block-B, Type-V, Dr Rajendra Prasad Government Medical College, Kangra at Tanda, Himachal Pradesh, India.
 
Email
seema406@rediffmail.com
 
Abstract
There are very few cases of neonatal empyema described in medical literature. There is no standard treatment protocol currently available. We report 3 neonates with late onset sepsis and thoracis empyema. Two had one sided and one had bilateral thoracis empyema. All 3 of them grew staphylococcus aureus on culture. All the three neonates required initial chest tube drainage along with administration of antibiotics. They responded to the treatment.
 
Keywords
Antibiotics, Empyema, Neonate, Pneumonia
 
Introduction
Empyema is defined as pus in the pleural space. It is typically a complication of pneumonia. However, it can also arise from penetrating chest trauma, esophageal rupture, complication from lung surgery, or inoculation of the pleural cavity after thoracentesis or chest tube placement. An empyema can also occur from a sub-diaphragmatic or paravertebral abscess via an extension. It is seen frequently in children but is less common in neonates. (1) Various modalities of treatment from intravenous antibiotics, chest tube drainage, intra-pleural fibrinolytic agent instillation, video-assisted thoracostomy (VAT) to surgical decortication have been suggested to treat different stages of empyema in children, but management of progressive empyema in neonates is still at the stage of antimicrobial therapy and tube thoracostomy. (2) We present three neonates with empyema thoracis.
 
Case Report
Three term, appropriate for gestational age neonates were admitted with signs of respiratory distress in the neonatal intensive care unit at 13, 6 and 14 days of life respectively. The clinical characteristics are given in Table 1. The clinical impression was pleural effusion with late onset neonatal septicaemia. X-ray chest and ultrasound of thorax were suggestive of pleural effusion unilaterally in two patients (Figure 1) and bilateral in one patient. Diagnostic pleural tap was suggestive of empyema thoracis. All the three patients were started on antibiotic therapy at the time of admission and continued for 3 weeks. Thoracentesis was performed in all the patients. They received mechanical ventilation for 7-10 days. The hospital stay was from 3-4 weeks (Table 1). All of them responded to therapy and were discharged.

Table 1- Patients Characteristics
SR NO Patient Characteristics CASE 1 CASE 2 CASE 3
[A] History
1 Age (days) 13 6 14
2 Fever Yes Yes No
3 Lethargy Yes Yes Yes
4 Poor feeding Yes No Yes
5 Premature rupture of membranes duration (days) 18 24 16
6 Period of gestation (Weeks) 41 + 2 days 36 39 + 3 days
7 Maternal fever No No No
8 Mode of delivery Vaginal delivery Emergency LSCS in view of acute fetal distress Vaginal delivery
9 Birth asphyxia No No No
10 Birth weight (kg) 2.75 3.475 3.6
[B] Clinical Characteristics on presentation
1 Heart rate (Minute) 154 180 168
2 Temperature Afebrile 104o F Afebrile
3 Respiratory rate (Minute) 84 66 86
4 SpO2 at room air 76% 85% 87%
5 SpO2 with oxygen 92% 93% 99%
6 Subcostal /intercostal recession Yes No Yes
7 Stridor No No Yes
8 Respiratory System Absent air entry(left) with dull note on percussion Absent air entry in right infra-axillary, infra-mammary area with dull note on percussion Absent air entry in lower lung fields bilateral with dull note on percussion
9 Other systems Normal Normal Normal
[C] Laboratory parameters
  Hemogram
  Hemoglobin (gm/dl) 15.9 16 16.4
  White cell count (cells/cumm) 18,900 26,500 16,900
  Polymorph (%) 66 76 88
  Platelet count (cells/cumm) 1,25,000 75,000 114,000
  C-reactive protein (mg/dl) >48 <6 Between 6-12
  Pleural fluid      
  Gross appearance Turbid Turbid Turbid
  White cell count (cells/cumm) 97,600 192000 84,300
  Polymorph (%) 94 92 87
  Protein (gm/dl) 4.2 3.7 4
  Sugar (mg/dl) 2.8 2 2.4
  Gram stain Negative Negative Negative
  Culture No growth Staphylococcus aureus Staphylococcus aureus
  Endotracheal tube culture Staphylococcus aureus No growth Citrobacter spp
  Blood culture Sterile Sterile Sterile
[C] Treatment
  Antibiotics Vancomycin-21 days
Meropenem-14 days
Ciprofloxacin-10 days
Vancomycin-21 days
Cefotaxime-21 days
Vancomycin-21 days
Meropenem-14 days
Ciprofloxacin-10 days
  Duration of hospital stay 23 days 27 days 23 days


Note: LSCS =Lower segment caesarean section, SpO2 = Saturation of oxygen

Figure 1-X-ray Chest showing left pleural effusion

 
Discussion
There is an increased risk of parapneumonic empyema with extremes of age with rates of 7.6 and 9.9 cases per 100,000 for ages younger than 5 years and older than 64 years, respectively. Most pediatric patients with empyema are less than two years of age; however, fortunately neonatal pleural empyema is rare. (3) Empyema is more common in the poor socioeconomic group. The incidence peaks between 0-3 years of age. (4) It has variable predisposing factors, uncertain pathogenesis, rapid course, high mortality and there is lack of management protocol in neonates.The pathogens isolated from children with pleural empyema are Hemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus, Bacteroides species and other anaerobes. (5) All our patients had infection with S. aureus, which is one of the most common community acquired bacterial pathogens resulting into empyema infection.
The clinical signs may be limited in the newborn period; therefore, the typical stony dull percussion note observed in older children may be absent in the newborn. (6) All our patients had a dull note on percussion.
Key for the successful management lies in two basic principles, one is to start effective antibiotic therapy for 3-6 weeks duration along with effective pleural evacuation (for up to 1 week/ till tube thoracostomy yield is less than 50 ml of fluid per day) and the other is re-expansion of lungs. (7) Antibiotic should be continued until patient is afebrile, white cell count is normal and radiograph show consider-able clearing. Normally, H. influenzae and S. pneumoniae need 7-14 days course of antibiotics while S. aureus needs 3-4 weeks. (8) Other modalities that can be used are intra-pleural fibrinolytics and video assisted thoracoscopic surgery (VATS). The management of complicated parapneumonic effusions by conventional first-line treatment with closed intercostal tube drainage and antibiotic therapy may fail because of thick viscous fluid and multiple pleural space loculations. Intra-pleural fibrinolytic treatment is a non-invasive therapeutic option that avoids surgical intervention, although its use in neonates has not been studied extensively. Successful outcome have been reported following the use of fibrinolytics in neonates. (8) VATS can be a safe and effective treatment option for neonatal empyema. (9) All our patients responded to intercostal tube drainage and IV antibiotics.
 
Conclusion
Neonatal empyema thoracis is rare and most patients have S. aureus infection. Treatment with intercostal tube drainage with antibiotics is successful in these patients though a standard protocol with other treatment modalities needs to be established.
 
Funding
None
Conflict of Interest
None
References :
  1. Mazumdar J, Sen S. Neonatal Empyema Thoracis. J Nepal Paediatr Soc 2014; 34(1):65-67.
  2. Kaiser JR, Shrager JB. Video assisted thoracic surgery: The current state of the art. Am J Roentgenol 1995; 165: 1111-1117.
  3. Freij BJ, Kusmiesz H, Nelson JD, McCracken GH. Parapneumonic effusions and empyema in hospitalized children: a retrospective review of 227 cases. Pediatr Infect Dis 1984;3:578-91.
  4. Mangete EDO, Kombo BB, Legg-Jack TE. Thoracic empyema: A study of 56 patients. Arch Dis child 1993; 69: 587-588.
  5. Brusch JL, Weinstein L. Pleural empyemas. In: Feigin RD, Cherry JD, eds. Paediatric Infectious Diseases, 3rd edn. Philadelphia. WB Saunders. 1992:315-20.
  6. Jain SN, Banavaliker J. Bacteriological analysis of pleural fluid from the largest chest hospital in Delhi. J Empyema Thoracis. 2013;3:6-10.
  7. Winter RH. Non-malignant pleural effusion. In: Fishman FA (eds). Fishman’s Pulmonary Diseases and Dis-orders. 3rd edn. New York. McGraw Hill. 1998: 1411-1428.
  8. Cha LMJ, Choi S, Kim T, Yoon SW. Intrapleural urokinase therapy in a neonate with pleural empyema. Pediatrics International. 2016; 58: 616–619.
  9. Leung C, Chang YC. Video-assisted thoracoscopic surgery in a 1-month-old infant with pleural empyema. J Formos Med Assoc. 2006;105: 936-40.
Last Updated : 01 January 2018 Vol 15 Issue 1 Art #2
DOI: 10.7199/ped.oncall.2018.2
How to Cite URL :
Sharma S, Sharma A, Sharma M, Ghosh S. NEONATAL EMPYEMA THORACIS. Pediatric Oncall Journal [serial online] 2018[cited 2018 January-March 1];15. Art #2. Available From : http://www.pediatriconcall.com/pediatric-journal/View/fulltext-articles/1104/J/0/0/588/0
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.