Pediatric Oncall
facebook
twitter
youtube
instagram
rss
Home
Diseases and Conditions › Pediatric Hematology › Hemophilia

Hemophilia
Dr Ira Shah
More..
fb
twitter
print
How Is Hemophilia Diagnosed?
Prolonged PTT (Prothrombin thromboplastin time) with a normal PT (Prothrombin time) and normal bleeding time is suggestive of hemophilia. It is confirmed by doing the factor assay.

Chorionic villus biopsy at 8 weeks gestation on amniocentesis at 12-14 weeks can be used for prenatal diagnosis by DNA analysis if the mother's carrier state is demonstrated either by mutation analysis or Restriction Fragment Length polymorphism study. If DNA analysis is not available, fetal blood can be aspirated at 18-20 weeks gestation. If pure fetal blood is obtained, factor VIII activity can be assayed. If fetal blood mixed with amniotic fluid is obtained, factor VIII: Ag can be measured.

Most carriers have a factor VIII level between 30-70 U/dl. Factor VIII levels should be assayed in all females who might be carriers to identify those with levels below 30U/dL. These women should be treated the same way as male hemophiliac with similar factor levels.

Assays of factor VIII activity and VWF: Ag can be used to predict whether a given woman is a carrier. If the factor VIII level is below normal, then she is designated as a true carrier. If her factor VIII level is in the normal range, but her VWF :Ag is higher, then she is a true carrier.

When a definite diagnosis of the carrier state can not be made, the probability of being a carrier is calculated from family tree analysis.

Recently, carrier identification can be done by examination of factor VIII gene and DNA analysis and Restriction fragment length polymorphisms
Hemophilia Hemophilia 12/20/2000
<< Clinical Presentation Of Hemophilia How Is Hemophilia Treated? >>
ask a doctor
Ask a Doctor
Book Store
Infection In Children Infection In Children
Order Now
Join Us
facebook
twitter
youtube
instagram
rss
Pediatric Oncall
Pediatric Oncall
Medical Calculators
Medical Calculators
Drug Center
Drug Center
Pediatric Oncall Journal
Pediatric Oncall Journal
Parenting
Parenting
Vaccine Reminder
Vaccine Reminder

Home

 About Us
Link To Us
Terms & Conditions
Privacy Policy

 
Online Ordering Policy
Sitemap
Feedback

Partner Sites

HIV in Childern
Creative Catchy Ideas
Medical ADRIS
Vaccine Reminder
Pediatric Oncall Journal
Infection in Children - Part 3

New Arrival

Infection in Children - Part 3

Other Pediatric Oncall Books
View More Books
DMCA
COPYSCAPE
Copyright © 2001 - 2019 Pediatric Oncall All Rights Reserved. All trademarks used are the properties of their respective owners.
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0