Drug Index

Methyl Dopa

Synonym :


Mechanism :

It is a centrally acing antihypertensive agent that acts on the central alpha receptors and is used in the treatment of mild to moderate hypertension.

Indication :

  • Treatment of refractory hypertension
  • Hypertensive crisis

Contraindications :

Active liver disease, pheochromocytoma, porphyria.

Dosing :

<12 years: 2.5 mg/kg PO thrice a day
12-18 years: 10 mg/kg/day PO in 2 divided doses.
Initial doses is to be increased at intervals of 2 or more days to a maximum of 15 mg/kg 3 times daily in neonates; 5 mg/kg/day or 3 g/day in older children and adults.
Hypertensive crisis:
20-40 mg/kg/day IV in 4 divided doses. Max dose: 65 mg/kg/day or 3 g/day.

Adverse Effect :

Sedation, dizziness, depression, lethargy, dry mouth, reduced mental capacity, rash, gynecomastia, galactorrhoea, impotence, arthralgia, nasal stuffiness, weight gain and postural hypotension. Positive Coombs test, thrombocytopenia, cholestatic liver damage, bradycardia may also be seen.

Interaction :

Potentiation of other antihypertensives.
NSAIDS: Antagonise the antihypertensive effect.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function and adjust according to response
10-20Dose as in normal renal function and adjust according to response
<10Dose as in normal renal function and adjust according to response

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in GFR<10 mL/ min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDProbably dialysed. Dose as in GFR=10–20 mL/min

Hepatic Dose :

Use is contraindicated in patients with active hepatic disease.
03/24/2024 12:34:32 Methyl Dopa
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