Mitchell Lester
Anaphylaxis - Introduction
Abbreviations used:
FceR1: High affinity IgE receptor
IgE: Immunoglobulin E
IgG: Immunoglobulin G
NSAID: Non-steroidal anti-inflammatory drug
NPV: Negative predictive value
PPV: Positive predictive value
RAST: Radioallergosorbent test

Anaphylaxis is a relatively common and potentially life-threatening occurrence in the pediatric population. Fortunately, anaphylactic deaths are rare with potentially life-saving early intervention.

Anaphylaxis was described in 1902 by Frenchmen Richet and Portier. In their efforts to immunize dogs to sea anemone toxin, some dogs who previously tolerated sub-lethal doses died after receiving even smaller doses. They coined the term “anaphylaxis” (“without protection”), literally the opposite of prophylaxis. Richet received the 1913 Nobel Prize in Medicine for their work.

The incidence of anaphylaxis increased in the late 20th century with rates as high as 50/100,000 person-years. The prevalence of anaphylaxis in North America is about 1%. Every year in the United States an estimated 150 anaphylactic deaths are attributable to food, 50 to venom, and up to 600 from medications. The incidence and prevalence appear to be highest in children and decrease with age.

This review will stress the importance of early recognition and treatment of anaphylaxis and identify its most common causes.

Anaphylaxis Anaphylaxis 04/19/2016
Recognition and Mechansims of Anaphyalxis >>
ask a doctor
Ask a Doctor
Disclaimer: The information given by is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0