Drug Index


Mechanism :

Ampicillin trihydrate is a semisynthetic penicillin. Sulbactam is a beta lactamase inhibitor, which enhances action of ampicillin against beta-lactam producing strains of Staph aureus and other organisms.

Indication :

  • Like that of ampicillin
  • Useful to treat Acinetobacter baumannii infections

Contraindications :

A history of hypersensitivity to any penicillin is a contraindication. Infectious mononucleosis patients develop a rash, and therefore use is avoided. Renal and hepatic function should be monitored.

Dosing :

IV: 100-200 mg ampicillin/kg/day divided every 6 hourly. For meningitis: 200-400 mg
ampicillin/kg/dose divided every 6 hours. Maximum dose: 8 gm ampicillin in a day.

Adverse Effect :

Nausea, vomiting, diarrhea, pseudomembranous colitis, black hairy tongue, serum sickness-like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, hypersensitivity vasculitis, urticaria.

Interaction :

Probenecid: Decreases the renal tubular secretion of amoxicillin, concurrent use may result in increased and prolonged blood levels of amoxicillin.
Warfarin: Prolongation of prothrombin time.
OCPs: Decreased effectiveness.
Allopurinol: Increases frequency of rashes.
Chloroquine: Reduces absorption of ampicillin.

Hepatic Dose :

No dosage adjustments are recommended.
01/18/2024 20:07:43 Ampicillin/Sulbactam
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