Drug Index


Mechanism :

It is a semisynthetic penicillin which acts by inhibiting the bacterial cell wall synthesis. It is penicillate sensitive and is effective against gram positive organisms and gram-negative microorganisms but is inactive against beta-lactamase producing organisms. It is an analog of ampicillin.

Indication :

  • Infections of the ear, nose, and throat
  • Infections of the genitourinary tract
  • Infections of the skin and skin structure
  • Infections of the lower respiratory tract
  • Gonorrhoea, acute uncomplicated
  • Anthrax (off-label)
  • Infective Endocarditis (off-label)
  • Lyme Disease (off-label)

Contraindications :

A history of hypersensitivity to any penicillin is a contraindication. Infectious mononucleosis patients develop a rash, and therefore use is avoided. Renal and hepatic function should be monitored.

Dosing :

Mild infections:
Oral; 30-40 mg/kg/day in three divided doses for 7-10 days.
Severe infections:
Intra-venous; 100 mg/kg/day in two-three divided doses for 7-14 days.

Adverse Effect :

Nausea, vomiting, diarrhea, serum sickness-like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis, anaphylaxis, pseudomembranous colitis, AST/ALT elevation, anemia and urticaria.

Interaction :

Chloramphenicol, Macrolides, Sulphonamides, And Tetracyclines: Interfere with bactericidal action of amoxycillin.
Probenecid: Decreases the renal tubular secretion of amoxicillin, concurrent use may result in increased and prolonged blood levels of amoxicillin.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10250 mg – 1 g every 8 hours (Maximum 6 g per day in endocarditis)

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
03/13/2024 07:08:46 Amoxicillin
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