Drug Index

Amoxicillin

 
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Mechanism :

It is a semisynthetic penicillin which acts by inhibiting the bacterial cell wall synthesis. It is penicillate sensitive and is effective against gram positive organisms and gram-negative microorganisms but is inactive against beta-lactamase producing organisms. It is an analog of ampicillin.


Indication :

• Infections of the ear, nose, and throat

• Infections of the genitourinary tract

• Infections of the skin and skin structure

• Infections of the lower respiratory tract

• Gonorrhoea, acute uncomplicated

• Anthrax (off-label)

• Infective Endocarditis (off-label)

• Lyme Disease (off-label)


Contraindications :

A history of hypersensitivity to any penicillin is a contraindication. Infectious mononucleosis patients develop a rash, and therefore use is avoided. Renal and hepatic function should be monitored.


Dosing :

Mild infections:

Oral; 30-40 mg/kg/day in three divided doses for 7-10 days.

Severe infections:

Intra-venous; 100 mg/kg/day in two-three divided doses for 7-14 days.


Adverse Effect :

Nausea, vomiting, diarrhea, serum sickness-like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis, anaphylaxis, pseudomembranous colitis, AST/ALT elevation, anemia and urticaria.


Interaction :

Chloramphenicol, Macrolides, Sulphonamides, And Tetracyclines: Interfere with bactericidal action of amoxycillin.
Probenecid: Decreases the renal tubular secretion of amoxicillin, concurrent use may result in increased and prolonged blood levels of amoxicillin.


07/19/2019 03:33:42 Amoxicillin
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