Drug Index

Cloxacillin

 
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Synonym :

Dicloxacillin

Mechanism :

It is a penicillin derivative which acts by inhibiting the bacterial cell wall synthesis. It is penicillate sensitive and is effective against gram positive organisms especially staphylococcal aureus and gram-negative microorganisms.


Indication :

• Infections caused by methicillin sensitive staphylococcus aureus (MSSA)


Contraindications :

Penicillin hypersensitivity.


Dosing :

Newborn: IV/Oral

<7 days: 50-100 mg/kg/day in 2 divided doses.

7-21 days: 75-150 mg/kg/day in 3 divided doses.

>21 days: 100-200 mg/kg/day in 4 divided doses.

Children:

IV/IM: 50-100 mg/kg/day in 4 divided doses (Max single dose 1 gm-may be doubled in severe infection).

Oral: <1 year: 250 mg/day; 1-5 years: 500 mg/day; 5-18 years: 1 gm in 4 divided doses.


Adverse Effect :

Gastrointestinal effects, particularly at high oral doses, skin rash, hepatitis, cholestatic jaundice, pseudomembranous colitis.


Interaction :

Warfarin: Prothrombin time may be increased.


08/11/2019 21:04:27 Cloxacillin
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