Drug Index

Hyoscine Butyl Bromide

 
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Mechanism :

Hyoscine Butylbromide exhibits mild anticholinergic and spasmolytic atropine-like actions and possesses marked ganglionic blocking and curariform properties. Hyoscine Butylbromide is devoid of central nervous actions. Reduces peristalsis without loss of tone in peptic ulcer therapy; reduces spasm in gastrointestinal, biliary, and renal conditions.


Indication :

• Abdominal colic

• Renal colic


Contraindications :

Contraindicated in patients with myasthenia gravis, megacolon, glaucoma and in patients with known hypersensitivity to hyoscine butylbromide.


Dosing :

Oral:

5-12 years: 10 mg/dose 3-4 times daily.

12-18 years: 20 mg/dose 3-4 times daily.

IM/IV: Max: 1.2 mg/kg/day.

<6 years: 5 mg/dose 3-4 times daily.

6-12 years: 5-10 mg/dose 3-4 times daily.

>12 years: 20 mg/dose 3-4 times daily.


Adverse Effect :

Dry mouth, constipation, tachycardia, visual accommodation disturbances, and urinary retention. Less commonly: rash, itching, swelling of the hands or feet, dizziness, diarrhea, vision problems.


Interaction :

Tricyclic Antidepressants, Antihistamines, Quinidine, Amantadine, Phenothiazines, Butyrophenones and Disopyramide: Increased anticholinergic effects.
Metoclopramide: Con­comitant treatment may decrease effect of both drugs on gastrointestinal tract.
Beta-agonists: Tachycardic ef­fects may be en­hanced.


08/11/2019 21:03:25 Hyoscine Butyl Bromide
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