Hyoscine Butyl Bromide

Mechanism :

Hyoscine Butylbromide exhibits mild anticholinergic and spasmolytic atropine-like actions and possesses marked ganglionic blocking and curariform properties. Hyoscine Butylbromide is devoid of central nervous actions. Reduces peristalsis without loss of tone in peptic ulcer therapy; reduces spasm in gastrointestinal, biliary, and renal conditions.

Indication :

• Abdominal colic
• Renal colic

Contraindications :

Contraindicated in patients with myasthenia gravis, megacolon, glaucoma and in patients with known hypersensitivity to hyoscine butylbromide.

Dosing :

Adverse Effect :

Dry mouth, constipation, tachycardia, visual accommodation disturbances, and urinary retention. Less commonly: rash, itching, swelling of the hands or feet, dizziness, diarrhea, vision problems.

Interaction :

Tricyclic Antidepressants, Antihistamines, Quinidine, Amantadine, Phenothiazines, Butyrophenones and Disopyramide: Increased anticholinergic effects.
Metoclopramide: Con­comitant treatment may decrease effect of both drugs on gastrointestinal tract.
Beta-agonists: Tachycardic ef­fects may be en­hanced.

Renal Dose :