Drug Index

Proguanil

 
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Synonym :

Atovaquone/ Proguanil

Mechanism :

Proguanil is an antimalarial drug used mainly in the prophylaxis of falciparum malaria.


Indication :

• Malaria prophylaxis and treatment along with atovaquone


Contraindications :

Hypersensitivity to drug/class/component, CrCl <30 (prophylaxis use).


Dosing :

Available as a 62.5 mg Atovaquone/25 mg Proguanil FDC (Pediatric strength) and 250 mg/100 mg Atovaquone/Proguanil FDC (Adult strength).

5-8 kg: 2 Pediatric tab OD

9-10 kg: 3 Pediatric tab OD

11-20 kg: 1 Adult tab OD

21-30 kg: 2 Adult tab OD

31-40 kg: 3 Adult tab OD

>40 kg: 4 Adult tab OD

Malaria prophylaxis:

11-20 kg: 1 Pediatric tablet daily

21-30 kg: 2 Pediatric tablets daily

31-40 kg: 3 Pediatric tablets daily

>40 kg: 4 Pediatric tablets daily

To be given 1 day before entering area and to be continued for 1 week after return. Contraindicated in pregnant women.


Adverse Effect :

Abdominal pain, headache, myalgia, nausea, increase LFTs, renal impairment, vertigo, rash, hematological abnormality.


Interaction :

Interaction Characteristics:
CYP2C19 substrate.
Contraindicated:
Auranofin, Gold sodium thiomalate.


08/10/2019 20:32:22 Proguanil
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