Drug Index



Mechanism :

Clarithromycin is a macrolide antibiotic.
It is first metabolized to 14-OH clarithromycin, which is active and works synergistically with its parent compound. Like other macrolides, it then penetrates bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump.

Indication :

• Pertussis

• Mycobacterium avium complex

• Community acquired pneumonia, sinusitis, bronchitis, skin infections

• Mycoplasma pneumonia

Contraindications :

Contraindicated in patients with known hypersensitivity to clarithromycin, or any other macrolide.

Dosing :

15 mg/kg/day PO in 2 divided doses for 7-10 days. Maximum dose: 500 mg/dose.

Adverse Effect :

Nausea, vomiting, abdominal pain, diarrhea, anorexia, altered taste sensation, stomatitis, glossitis, anxiety, dizziness, insomnia, altered liver function tests.

Interaction :

Theophylline: Increase in serum theophylline levels and potential theophylline toxicity.
Oral anticoagulants: Increased anticoagulant effects
Ergotamine or Dihydroergotamine: Acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.
Terfenadine, Astemizole and Cisapride: Risk of cardiac arrhythmias.

03/13/2020 23:29:37 Clarithromycin
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