Drug Index

Artemether

 
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Mechanism :

There are three common forms of artemisinin. The water-soluble form is called artesunate. It is the most active and the least toxic within the body. Artemether is the lipid soluble form. It has the longest life but also the most toxic in high dosage which is seldom needed. The biggest advantage of artemether is that it can cross the blood brain barrier. Artemisinin is the active parent compound of the plant. Its half-life is intermediate. It is also very safe and can cross the blood-brain barrier. Artemisinin has been shown to work through oxygen and carbon based free radical mechanisms. Artemether has been combined with lumefantrine for use as combination therapy orally.


Indication :

• Malaria


Contraindications :

First trimester of pregnancy.


Dosing :

3.2 mg/kg/IM loading dose followed by 1.6 mg/kg/IM after 24 hours & then 1.6 mg/kg/M 12 hourly till the child can eat orally. Then shift to oral therapy.

Artemether + Lumefantrine (Available as 20 mg of artemether + 120 mg lumefantrine FDC or 40 mg of artemether + 240 mg lumefantrine): oral therapy for 3 days.

5-14 kg: 20 mg of artemether + 120 mg of lumefantrine BID.

15-24 kg: 40 mg of artemether + 240 mg of lumefantrine BID.

25-34 kg: 60 mg of artemether + 360 mg of lumefantrine BID.

≥35 kg: 80 mg of artemether + 480 mg of lumefantrine BID.


Adverse Effect :

Gastrointestinal disturbances, dizziness, tinnitus and prolongation of QT interval.


Interaction :

Quinidine and halofantrine: Caution in concurrent usage with drugs that prolong QT interval.


07/17/2019 21:35:48 Artemether
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