Drug Index



Mechanism :

It is a leukotriene antagonist. Zafirlukast selectively antagonises the leukotriene D4 receptor. It inhibits bronchoconstriction caused by various inhaled antigens or irritants. It is not used in acute asthma attacks.

Indication :

• Chronic Asthma

Contraindications :

Hypersensitivity, Hepatic impairment, Cirrhosis, Acute asthmatic attacks.

Dosing :

Oral dose. Taken 1 hour before or 2 hours after meals.

<5 years of age: Safety and efficacy has not been established.

5-11 years: 10 mg bid.

>12 years: 20 mg bid.

Adverse Effect :

GI disturbances, headache, myalgia, generalised pain, fever, dizziness, raised LFT, respiratory tract infections, hypersensitivity reactions, Churg-Strauss syndrome, severe hepatotoxicity.

Interaction :

Aspirin: High dose aspirin increases plasma concentration of zafirlukast.

Theophylline, Terfenadine and Erythromycin: Zafirlukast plasma concentration is reduced. Warfarin: It enhances warfarin anticoagulant activity.

03/12/2020 01:56:23 Zafirlukast
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