Drug Index

Atenolol

 
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Mechanism :

Atenolol is a cardioselective beta-adrenergic receptor blocking agent without membrane stabilizing or intrinsic sympathomimetic activities.


Indication :

• Hypertension


Contraindications :

Atenolol is contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure. It should be avoided in asthmatics.


Dosing :

0.5 to 1 mg/kg/day orally; maximum daily dose: 2 mg/kg/day or 100 mg/day.


Adverse Effect :

Tiredness, bradycardia, postural hypotension, precipitation of heart block, intermittent claudication, Raynaud’s phenomena, depression, dizziness, confusion, mood changes, nightmares, hallucinations, paresthesia, vertigo, bronchospasm, hypoglycaemia, purpura, thrombocytopenia.


Interaction :

Calcium channel blockers: Additive effect.
Prostaglandin synthase inhibiting drugs: Decrease the hypotensive effects of beta blockers.
Catecholamine-depleting drugs such as reserpine: Hypotension, marked bradycardia, vertigo, syncopal attacks, or orthostatic hypotension.
Haloperidol: Hypotension and cardiac arrest.
Theophylline: Clearance is reduced.
Cimetidine: Increasing blood levels.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDDialysed. Dose as in normal renal function
HDF/High fluxDialysed. Dose as in normal renal function
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
08/05/2020 08:26:51 Atenolol
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