Drug Index

Anti-Thymocyte Immunoglobulin

Synonym :

ATG

Mechanism :

The possible mechanism may involve elimination of antigen-reactive T-lymphocytes (killer cells) in peripheral blood alteration of T-cell function.


Indication :

  • Treatment of acute rejection after renal transplant.
  • Treatment of aplastic anemia in patients.

Contraindications :

Hypersensitivity to antithymocyte globulin, rabbit proteins or any component; acute viral illness.


Dosing :

Renal transplantation rejection:

IV: 10 to 15 mg/kg/dose once daily for 14 days, then if needed, give alternate day up to a total of 21 doses in 28 days.

Aplastic Anemia:

10-20 mg/kg/day IV for 8-14 days and then every alternate day (total doses 21).


Adverse Effect :

Fever, thrombocytopenia, rash, leukopenia, rigors, infections, arthralgia, headache, diarrhea, hypertension, edema, thrombosis, anaphylaxis, proteinuria, serum sickness.


Interaction :

With other immunosuppressants: Additive immunosuppressive effects or over immunosuppression.



Hepatic Dose :

No dosage adjustments are recommended.
10/21/2023 16:28:29 Anti-Thymocyte Immunoglobulin
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