Drug Index

Anti-Thymocyte Immunoglobulin

Synonym :


Mechanism :

The possible mechanism may involve elimination of antigen-reactive T-lymphocytes (killer cells) in peripheral blood alteration of T-cell function.

Indication :

  • Treatment of acute rejection after renal transplant.
  • Treatment of aplastic anemia in patients.

Contraindications :

Hypersensitivity to antithymocyte globulin, rabbit proteins or any component; acute viral illness.

Dosing :

Renal transplantation rejection:

IV: 10 to 15 mg/kg/dose once daily for 14 days, then if needed, give alternate day up to a total of 21 doses in 28 days.

Aplastic Anemia:

10-20 mg/kg/day IV for 8-14 days and then every alternate day (total doses 21).

Adverse Effect :

Fever, thrombocytopenia, rash, leukopenia, rigors, infections, arthralgia, headache, diarrhea, hypertension, edema, thrombosis, anaphylaxis, proteinuria, serum sickness.

Interaction :

With other immunosuppressants: Additive immunosuppressive effects or over immunosuppression.

Hepatic Dose :

No dosage adjustments are recommended.
10/21/2023 16:28:29 Anti-Thymocyte Immunoglobulin
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0