Drug Index

Basiliximab

Mechanism :

Basiliximab is a chimeric (murine/human) monoclonal antibody (IgG1k), produced by recombinant DNA technology, that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2Ra, also known as CD25 antigen) on the surface of activated T-lymphocytes.


Indication :

  • Prophylaxis of acute organ rejection in patients receiving renal transplantation.

Contraindications :

Contraindicated in patients with known hypersensitivity to basiliximab or any other component of the formulation.


Dosing :

>35 kg:
20 mg IV within 2 hours before transplant, followed by 20 mg IV for 4 days following transplant (same as in adults);
<35 kg:
10 mg IV within 2 hours before transplant, followed by 10 mg IV for 4 days following transplant.
The second dose should be withheld if complications such as severe hypersensitivity reactions or graft loss occur.

Adverse Effect :

Constipation, nausea, abdominal pain, vomiting, diarrhea, dyspepsia, anaphylaxis, pain, peripheral edema, fever, hyperkalemia, hypokalemia, hyperglycemia, hypercholesterolemia, hypophosphatemia, hyperuricemia, dyspnea, acne, hypertension, headache, tremor, insomnia, anemia, infections.


Interaction :

The following medications have been administered concomitantly, with no increase in adverse reactions: ATG/ALG, Azathioprine, Corticosteroids, Cyclosporine, Mycophenolate Mofetil, And Muromonab-CD3.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
07/06/2024 00:55:06 Basiliximab
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