Drug Index

Beta Glucuronidase

 
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Synonym :

Vestronidase alfa-vjbk

Mechanism :

Vestronidase alfa-vjbk is a recombinant human beta-glucuronidase (GUS), which provides exogenous GUS enzyme for uptake into cellular lysosomes.


Indication :

• Mucopolysaccharidosis VII


Contraindications :

No contraindications.


Dosing :

IV: 4 mg/kg every 2 weeks.

Limitations of use: The effect of vestronidase alfa-vjbk on the CNS manifestations of MPS VII has not been determined.

Note: Premedicate with non-sedating antihistamines with/without antipyretics 30 to 60 minutes prior to the start of the infusion.


Adverse Effect :

Skin rash, diarrhea, anaphylaxis, antibody development, peripheral edema, pruritus, swelling at injection site, febrile seizures.


Interaction :

No known significant interactions.


07/19/2019 03:43:29 Beta Glucuronidase
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