Drug Index

Isradipine

 
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Mechanism :

Inhibits calcium ion from entering the “slow channels” or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarization, producing relaxation of vascular smooth muscle, resulting in coronary vasodilation and reduced blood pressure.


Indication :

• Hypertension


Contraindications :

Hypersensitivity to isradipine or any component of the formulation.


Dosing :

Off-label use:

Oral: Initial: 0.15-0.2 mg/kg/day in 3-4 divided doses; maximum 0.8 mg/kg/day, up to 20 mg daily.


Adverse Effect :

Headache, edema, flushing, tachycardia, palpitations, dizziness, skin rash, nausea, abdominal pain, diarrhea, weakness, urinary frequency, dyspnea.


Interaction :

Ondansetron: Isradipine and ondansetron both increase QTc interval.
Mefloquine: Mefloquine increases toxicity of isradipine by QTc interval.
CYP3A4 Inducers: May increase the metabolism of CYP3A4 Substrates.
CYP3A4 Inhibitors: May decrease the metabolism of CYP3A4 Substrates.
Levodopa: Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa.


07/14/2019 07:01:14 Isradipine
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