Drug Index

Canakinumab

 
print

Mechanism :

Canakinumab reduces inflammation by binding to interleukin-1 beta (IL-1beta) and preventing interaction with cell surface receptors.


Indication :

• Cryopyrin-associated periodic syndromes

• Familial Mediterranean fever

• Hyperimmunoglobulin D Syndrome (HIDS)/Mevalonate Kinase Deficiency (MKD)

• Tumor necrosis factor (TNF) receptor associated periodic syndrome (TRAPS)

• Systemic juvenile idiopathic arthritis: Treatment of active systemic juvenile idiopathic arthritis (SJIA) in patients 2 years and older.


Contraindications :

Hypersensitivity to canakinumab or any component of the formulation.


Dosing :

Subcutaneous

Cryopyrin-associated periodic syndromes (CAPS):

Children =4 years and Adolescents: 15 to 40 kg: 2 mg/kg every 8 weeks; may increase to

3 mg/kg if response inadequate.

Familial Mediterranean Fever (FMF), Hyperimmunoglobulin D Syndrome (HIDS)/Mevalonate Kinase Deficiency (MKD), Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS): Subcutaneous:

150 mg (>40 kg) or 2 mg/kg (=40 kg) every 4 weeks; may increase to 300 mg (>40 kg) or 4 mg/kg (=40 kg) every 4 weeks if response is not adequate.

Systemic juvenile idiopathic arthritis (SJIA):

Children ≥2 years and ≥7.5 kg and Adolescents: 4 mg/kg every 4 weeks. Maximum: 300 mg per dose).


Adverse Effect :

Headache, vertigo, weight gain, diarrhea, upper abdominal pain, nausea, infection, influenza, injection site reaction, musculoskeletal pain, nasopharyngitis, rhinitis, hypocalcemia, proteinuria, neutropenia, eosinophilia, thrombocytopenia, hyperbilirubinemia, antibody development.


Interaction :

Anti-TNF Agents: May enhance the adverse/toxic effect of Canakinumab. Specifically, the risk for serious infections and/or neutropenia may be increased.
Interleukin-1 Inhibitors: May enhance the adverse/toxic effect of Canakinumab.
Vaccines (Live): Immunosuppressants may enhance the adverse/toxic effect of Vaccines.


07/13/2019 00:29:10 Canakinumab
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0