Drug Index

Carbimazole

 
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Mechanism :

It prevents the peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the T3/T4.


Indication :

• Hyperthyroidism

• Diffuse toxic goitre

• Graves’ disease

• Neonatal thyrotoxicosis


Contraindications :

Contraindicated in hyperthyroidism due to nodular goiter and in liver disease.


Dosing :

15 mg/day orally.


Adverse Effect :

Bone marrow suppression causing neutropenia and agranulocytosis, nausea, headache, rashes, pruritus and arthralgia, alopecia, jaundice.


Interaction :

Warfarin: Increased sensitivity to warfarin.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Mild to moderate hepatic impairment: Use with caution. If abnormal liver function is discovered, the treatment should be stopped. The half-life may be prolonged due to the liver disorder.
Severe hepatic impairment: Contraindicated.
05/23/2020 14:25:30 Carbimazole
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