Drug Index


Mechanism :

It prevents the peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the T3/T4.

Indication :

  • Hyperthyroidism
  • Diffuse toxic goitre
  • Graves’ disease
  • Neonatal thyrotoxicosis

Contraindications :

Contraindicated in hyperthyroidism due to nodular goiter and in liver disease.

Dosing :

15 mg/day orally.

Adverse Effect :

Bone marrow suppression causing neutropenia and agranulocytosis, nausea, headache, rashes, pruritus and arthralgia, alopecia, jaundice.

Interaction :

Warfarin: Increased sensitivity to warfarin.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Mild to moderate hepatic impairment: Use with caution. If abnormal liver function is discovered, the treatment should be stopped. The half-life may be prolonged due to the liver disorder.
Severe hepatic impairment: Contraindicated.
03/23/2024 04:03:50 Carbimazole
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