Drug Index

Carbimazole

 
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Mechanism :

It prevents the peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the T3/T4.


Indication :

• Hyperthyroidism

• Diffuse toxic goitre

• Graves’ disease

• Neonatal thyrotoxicosis


Contraindications :

Contraindicated in hyperthyroidism due to nodular goiter and in liver disease.


Dosing :

15 mg/day orally.


Adverse Effect :

Bone marrow suppression causing neutropenia and agranulocytosis, nausea, headache, rashes, pruritus and arthralgia, alopecia, jaundice.


Interaction :

Warfarin: Increased sensitivity to warfarin.


07/19/2019 03:05:23 Carbimazole
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