Drug Index

Cefoxitin

 
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Mechanism :

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs)


Indication :

• Bone and joint infections

• Intra-abdominal infections

• Lower respiratory tract infections

• Skin and skin structure infections

• Urinary tract infections


Contraindications :

Hypersensitivity to cefoxitin, any component of the formulation, or other cephalosporins.


Dosing :

Infants >3 months and Children:

Mild to moderate infection: IV 80 mg/kg/day in divided doses every 6 to 8 hours. Maximum daily dose: 4,000 mg daily.

Severe infection: IV 160 mg/kg/day in divided doses every 4 to 6 hours. Maximum daily dose: 12 g daily.


Adverse Effect :

Diarrhea, Anaphylaxis, angioedema, bone marrow depression, dyspnea, eosinophilia, exacerbation of myasthenia gravis, exfoliative dermatitis, fever, hemolytic anemia, hypotension, increased blood urea nitrogen, increased serum creatinine, increased serum transaminases, interstitial nephritis, jaundice, leukopenia, nausea, nephrotoxicity.


Interaction :

Aminoglycosides: Cephalosporins (2nd Generation) may enhance the nephrotoxic effect of Aminoglycosides.
Probenecid: May increase the serum concentration of Cephalosporins.
Vitamin K Antagonists (e.g., Warfarin): Cephalosporins may enhance the anticoagulant effect of Vitamin K Antagonists.


07/14/2019 06:47:14 Cefoxitin
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