Drug Index

Chenodeoxycholic acid

 
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Mechanism :

Chenodeoxycholic acid is a bile acid. Chenodeoxycholic acid is synthetized in the liver from cholesterol.


Indication :

• Cerebrotendinous xanthomatosis

• Bile acid synthesis defects

• Smith -Lemli- Opitz Syndrome


Contraindications :

Peptic ulcer and inflammatory disease of small intestine and large intestine.


Dosing :

Cerebrotendinous xanthomatosis: 5 mg/kg/dose TDS.

Bile acid synthesis defects: Initially 5 mg/kg/dose TDS, then 2.5 mg/kg TDS.

Others: 7 mg/kg/dose in single or divided doses.


Adverse Effect :

Diarrhea.


Interaction :

Cholestyramine: Binds bile acids.
Aluminium hydroxide: May interfere with the absorption of chenodeoxycholic acid.
Oestrogenic Hormones, Oestrogen-rich OCPs and certain Blood Cholesterol Lowering Agents: Increase cholesterol elimination in bile, should not be used concurrently with chenodeoxycholic acid.
Cyclosporine: Increases absorption of cyclosporine.


07/14/2019 19:41:01 Chenodeoxycholic acid
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