Drug Index

Chenodeoxycholic acid

Mechanism :

Chenodeoxycholic acid is a bile acid. Chenodeoxycholic acid is synthetized in the liver from cholesterol.

Indication :

  • Cerebrotendinous xanthomatosis
  • Bile acid synthesis defects
  • Smith -Lemli- Opitz Syndrome

Contraindications :

Peptic ulcer and inflammatory disease of small intestine and large intestine.

Dosing :

Cerebrotendinous xanthomatosis:
5 mg/kg/dose TDS.
Bile acid synthesis defects:
Initially 5 mg/kg/dose TDS, then 2.5 mg/kg TDS.
7 mg/kg/dose in single or divided doses.

Adverse Effect :


Interaction :

Cholestyramine: Binds bile acids.
Aluminium hydroxide: May interfere with the absorption of chenodeoxycholic acid.
Oestrogenic Hormones, Oestrogen-rich OCPs and certain Blood Cholesterol Lowering Agents: Increase cholesterol elimination in bile, should not be used concurrently with chenodeoxycholic acid.
Cyclosporine: Increases absorption of cyclosporine.

Hepatic Dose :

Contraindicated for use in presence of known hepatocyte dysfunction or bile duct abnormalities.
03/20/2024 21:31:30 Chenodeoxycholic acid
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