Drug Index

Ciclesonide

 
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Mechanism :

Ciclesonide is a nonhalogenated, glucocorticoid prodrug that is hydrolysed to the pharmacologically active metabolite des-ciclesonide following administration. Des-ciclesonide has a high affinity for the glucocorticoid receptor and exhibits anti-inflammatory activity.


Indication :

• Asthma


Contraindications :

Hypersensitivity to ciclesonide or any component of the formulation; status asthmaticus or other acute asthma episodes requiring intensive measures.


Dosing :

Inhalation:

≤5 years: 160 mcg daily.

6 to 11 years: 80-160 mcg daily.

≥12 years: 80-320 mcg daily.


Adverse Effect :

Headache, nasopharyngitis, facial edema, dizziness, fatigue, voice disorder, urticarial, gastroenteritis, oral candidiasis, influenza, arthralgia, URTI, paradoxical bronchospasm.


Interaction :

Amphotericin B: Corticosteroids (Orally Inhaled) may enhance the hypocalcemic effect of Amphotericin B.
Deferasirox: Corticosteroids may enhance the adverse/toxic effect of Deferasirox. Specifically, the risk for GI ulceration/irritation or GI bleeding may be increased.
Desmopressin: Corticosteroids (Orally Inhaled) may enhance the hyponatremic effect of Desmopressin.
Loop Diuretics: Corticosteroids (Orally Inhaled) may enhance the hypocalcemic effect of Loop Diuretics.
Thiazide and Thiazide-Like Diuretics: Corticosteroids (Orally Inhaled) may enhance the hypocalcemic effect of Thiazide and Thiazide-Like Diuretics.


07/19/2019 03:07:39 Ciclesonide
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