Drug Index

Clarithromycin

 
print

Mechanism :

Clarithromycin is a macrolide antibiotic.
It is first metabolized to 14-OH clarithromycin, which is active and works synergistically with its parent compound. Like other macrolides, it then penetrates bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump.


Indication :

• Pertussis

• Mycobacterium avium complex

• Community acquired pneumonia, sinusitis, bronchitis, skin infections

• Mycoplasma pneumonia


Contraindications :

Contraindicated in patients with known hypersensitivity to clarithromycin, or any other macrolide.


Dosing :

15 mg/kg/day PO in 2 divided doses for 7-10 days. Maximum dose: 500 mg/dose.


Adverse Effect :

Nausea, vomiting, abdominal pain, diarrhea, anorexia, altered taste sensation, stomatitis, glossitis, anxiety, dizziness, insomnia, altered liver function tests.


Interaction :

Theophylline: Increase in serum theophylline levels and potential theophylline toxicity.
Oral anticoagulants: Increased anticoagulant effects
Ergotamine or Dihydroergotamine: Acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.
Terfenadine, Astemizole and Cisapride: Risk of cardiac arrhythmias.


07/18/2019 12:11:44 Clarithromycin
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0