Drug Index

Denosumab

 
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Mechanism :

Denosumab is a monoclonal antibody with affinity for nuclear factor-kappa ligand (RANKL).


Indication :

• Hypercalcemia of malignancy

• Glucocorticoid- induced osteoporosis

• Bone metastases from solid tumors

• Giant cell tumor of bone

• Osteoporosis/bone loss

• Multiple myeloma


Contraindications :

Hypersensitivity (systemic) to denosumab or any component of the formulation; pre-existing hypocalcemia; pregnancy.


Dosing :

13 to 17 years:

Giant cell tumor of bone: SC: 120 mg once every 4 weeks; during the first month, give an additional 120 mg on days 8 and 15.


Adverse Effect :

Peripheral edema, hypertension, fatigue, headache, skin rash, dermatitis, eczema, hypophosphatemia, hypocalcemia, diarrhea, nausea, constipation, anemia, thrombocytopenia, weakness, dyspnea, cough.


Interaction :

Belimumab: Monoclonal Antibodies may enhance the adverse/toxic effect of Belimumab.
Immunosuppressants: Denosumab may enhance the adverse/toxic effect of immunosuppressants. Specifically, the risk for serious infections may be increased.


07/14/2019 19:28:18 Denosumab
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