Drug Index

Dichloroacetate

 
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Mechanism :

Dichloroacetic acid is an analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. It is prepared by the reduction of trichloroacetic acid. It is used in treatment of metabolic dysfunctions.


Indication :

• Lactic acidosis

• Pyruvate dehydrogenase defects

• Pyruvate metabolism disorders

• Removing skin growths


Contraindications :

Long term use can cause polyneuropathy.


Dosing :

Oral: 12.5 mg/kg/dose 4 times daily, Max: 200 mg/kg/day used.


Adverse Effect :

Long term use can cause polyneuropathy.

Most commonly seen side effect is polyneuropathy. Abnormalities in oxalate metabolism, metabolic acidosis and an increase in glycerol in CSF have been reported.

07/15/2019 05:43:07 Dichloroacetate
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