Dornase Alpha

Synonyms :

Recombinant Human Deoxyribonuclease, rhDNase

Mechanism :

Dornase alfa is a highly purified solution of recombinant human deoxyribonuclease 1 (rhDNase), an enzyme which selectively cleaves DNA.

Indication :

Cystic fibrosis. It hydrolyses the DNA present in sputum/mucus of cystic fibrosis patients and reduces viscosity in the lungs.

Contraindications :

Patients with known hypersensitivity to dornase alfa, Chinese Hamster Ovary cell products or any component of the product.

Dosing :

2.5 mg as a nebulized solution once or twice daily.

Adverse Effect :

Abdominal pain, chest pain, pharyngitis, rhinitis, flu syndrome, urticaria, alteration in voice.

Interaction :

Can be effectively and safely used in conjunction with standard cystic fibrosis therapies including oral, inhaled and/or parenteral antibiotics, bronchodilators, enzyme supplements, vitamins, oral or inhaled corticosteroids, and analgesics. No formal drug interaction studies have been performed.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)

20-50	Dose as in normal renal function
10-20	Dose as in normal renal function
<10	Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies

CAPD	Unlikely to be dialysed. Dose as in normal renal function
HD	Unlikely to be dialysed. Dose as in normal renal function
HDF/High flux	Unlikely to be dialysed. Dose as in normal renal function
CAV/VVHD	Unlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.