Drug Index


Mechanism :

Ecallantide is a recombinant protein which inhibits the conversion of high molecular weight kininogen to bradykinin by selectively and reversibly inhibiting plasma kallikrein.

Indication :

  • Treatment of acute attacks of hereditary angioedema (HAE) in patients 12 years and older.

Contraindications :

Hypersensitivity to ecallantide or any component of the formulation.

Dosing :

SC: 30 mg. If attack persists, may repeat an additional 30 mg within 24 hours.

Adverse Effect :

Headache, nausea, fatigue, antibody development, skin rash, pruritus, urticarial, vomiting, anaphylaxis, injection site reactions, URTI, fever.

Interaction :

No known significant interactions.

Hepatic Dose :

No dosage adjustments are recommended.
12/21/2023 20:41:53 Ecallantide
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