Drug Index

Ecallantide

 
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Mechanism :

Ecallantide is a recombinant protein which inhibits the conversion of high molecular weight kininogen to bradykinin by selectively and reversibly inhibiting plasma kallikrein.


Indication :

• Treatment of acute attacks of hereditary angioedema (HAE) in patients 12 years and older.


Contraindications :

Hypersensitivity to ecallantide or any component of the formulation.


Dosing :

SC: 30 mg. If attack persists, may repeat an additional 30 mg within 24 hours.


Adverse Effect :

Headache, nausea, fatigue, antibody development, skin rash, pruritus, urticarial, vomiting, anaphylaxis, injection site reactions, URTI, fever.


Interaction :

No known significant interactions.


07/19/2019 03:26:08 Ecallantide
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