Elosulfase Alfa
Mechanism :
Elosulfase alfa is a recombinant form of N-acetylgalactosamine-6-sulfatase, produced in Chinese hamster cells.
Indication :
- Mucopolysaccharidosis type IVA (Morquio A syndrome)
Contraindications :
No contraindications.
Dosing :
≥9 months:
IV 2 mg/kg once weekly.
Adverse Effect :
Headache, vomiting, nausea, abdominal pain, hypersensitivity reaction, fever, chills, fatigue, anaphylaxis.
Interaction :
No known significant interactions.
Hepatic Dose :
Specific guidelines for dosage adjustments in hepatic impairment are not available.