Drug Index


Mechanism :

Enfuvirtide interferes with the entry of HIV-1 into cells by inhibiting fusion of viral and cellular membranes. Enfuvirtide binds to the first heptad-repeat (HR1) in the gp41 subunit of the viral envelope glycoprotein and prevents the conformational changes required for the fusion of viral and cellular membranes.

Indication :

  • HIV-1 infection in treatment-experienced patients with evidence of HIV-1 replication despite ongoing antiretroviral therapy

Contraindications :

Contraindicated in patients with known hypersensitivity to any of its components.

Dosing :

<6 years:
Safety and efficacy not established.
6-16 years:
2 mg/kg twice daily up to a maximum dose of 90 mg twice daily SC.
>16 years:
90 mg SC, twice a day.

Adverse Effect :

Local injection site reactions, diarrhea, nausea, fatigue, peripheral neuropathy, insomnia, anorexia, myalgia, flu like symptoms, Guillain Barre syndrome, hypersensitivity.

Interaction :

CYP450 Metabolized Drugs: Enfuvirtide is unlikely to have significant drug interactions with concomitantly administered drugs metabolized by CYP450 enzymes.
Antiretroviral Agents: No drug interactions with other antiretroviral medications have been identified that would warrant alteration of either the enfuvirtide dose or the dose of the other antiretroviral medication.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
35-50Dose as in normal renal function
10-35Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HD13% dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnlikely to be dialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnlikely to be dialysed. Dose as in GFR=10–35 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
01/24/2024 19:25:30 Enfuvirtide
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